Changes in denervated skeletal muscle of amiodarone‐fed mice
Identifieur interne : 003261 ( Main/Exploration ); précédent : 003260; suivant : 003262Changes in denervated skeletal muscle of amiodarone‐fed mice
Auteurs : Frederic R. Costa-Jussà [Royaume-Uni] ; Ana Guevara ; Gary A. Brook [Royaume-Uni] ; Leo W. Duchen [Royaume-Uni] ; Jean M. Jacobs [Royaume-Uni]Source :
- Muscle & Nerve [ 0148-639X ] ; 1988-06.
English descriptors
- Teeft :
- Absolute values, Acid phosphatase, Acid phosphatase activity, Amiodarone, Amiodarone toxicity, Autophagic vacuoles, Axonal regeneration, Biochemical studies, Body weight, Central nuclei, Checkerboard pattern, Cholinesterase activity, Clin pathol, Control animals, Control mice, Crush, Days dosing liver, Deeper parts, Denervated, Denervated muscle, Denervated muscles, Denervation, Dosing, Electron micrograph, Electron microscopy, Electrondense cores, Empty vacuoles, Endothelial cells, Endplate, Gastrocnemius muscle, Granular material, High oxidative enzyme activity, Higher oxidative enzyme activity, Histochem cytochem, Histochemical, Histochemical methods, Histochemical studies, Inclusion, Innervated, Innervated muscles, Intramuscular nerves, Jacobs, June, Lateral head, Lateral heads, Liquid chromatography, Many muscle fibers, Methyl cellulose, Mice muscle nerve june, Miniature endplate potentials, Motor function, Mouse, Muscle fiber regeneration, Muscle fibers, Muscle necrosis, Muscle nerve june, Muscle tensions, Myosin atpase, Necrosis, Necrotic fibers, Nerve, Nerve crush, Nerve crush figure, Nerve fibers, Nerve regeneration, Oxidative, Peripheral neuropathy, Physiological methods, Present study, Regeneration, Sarcoplasmic reticulum, Satellite cells, Sciatic, Sciatic nerve, Sciatic nerve crush, Second week, Serum proteins, Significant increase, Silver impregnation, Skeletal muscle, Skeletal muscles, Soleus, Soleus muscle, Spheromembranous bodies, Spheromembranous inclusions, Staining fibers, Vacuole, Vesicular structures.
Abstract
Prolonged dosing of mice with amiodarone produced a myopathy characterized by autophagic vacuolation and phospholipid inclusions. A previous morphological study had shown that amiodarone did not affect the rate of nerve regeneration after sciatic nerve crush. In the present study, reinnervation was assessed by the reappearance of miniature endplate potentials that confirmed that axonal regeneration and motor reinnervation was not affected by amiodarone. However, there was a marked delay in the recovery of motor function in the amiodarone‐treated mice. Denervation was found to induce an extensive necrosis of muscle fibers in the deeper parts of fast‐twitch muscles. Histochemical studies showed that type 1 fibers were spared, necrosis affecting mainly type 2 fibers with relatively high oxidative enzyme activity (fast‐twitch oxidative fibers). Biochemical studies showed a significant increase in the amount of amiodarone and its metabolite in denervated muscle of amiodarone‐treated mice when compared with contralateral, normally innervated muscles.
Url:
DOI: 10.1002/mus.880110616
Affiliations:
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Brook</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Department of Neuropathology, Institute of Neurology and The National Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Duchen, Leo W" sort="Duchen, Leo W" uniqKey="Duchen L" first="Leo W." last="Duchen">Leo W. Duchen</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Department of Neuropathology, Institute of Neurology and The National Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Jacobs, Jean M" sort="Jacobs, Jean M" uniqKey="Jacobs J" first="Jean M." last="Jacobs">Jean M. 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A previous morphological study had shown that amiodarone did not affect the rate of nerve regeneration after sciatic nerve crush. In the present study, reinnervation was assessed by the reappearance of miniature endplate potentials that confirmed that axonal regeneration and motor reinnervation was not affected by amiodarone. However, there was a marked delay in the recovery of motor function in the amiodarone‐treated mice. Denervation was found to induce an extensive necrosis of muscle fibers in the deeper parts of fast‐twitch muscles. Histochemical studies showed that type 1 fibers were spared, necrosis affecting mainly type 2 fibers with relatively high oxidative enzyme activity (fast‐twitch oxidative fibers). Biochemical studies showed a significant increase in the amount of amiodarone and its metabolite in denervated muscle of amiodarone‐treated mice when compared with contralateral, normally innervated muscles.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Guevara, Ana" sort="Guevara, Ana" uniqKey="Guevara A" first="Ana" last="Guevara">Ana Guevara</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Costa Ussa, Frederic R" sort="Costa Ussa, Frederic R" uniqKey="Costa Ussa F" first="Frederic R." last="Costa-Jussà">Frederic R. Costa-Jussà</name></region><name sortKey="Brook, Gary A" sort="Brook, Gary A" uniqKey="Brook G" first="Gary A." last="Brook">Gary A. Brook</name><name sortKey="Duchen, Leo W" sort="Duchen, Leo W" uniqKey="Duchen L" first="Leo W." last="Duchen">Leo W. Duchen</name><name sortKey="Jacobs, Jean M" sort="Jacobs, Jean M" uniqKey="Jacobs J" first="Jean M." last="Jacobs">Jean M. Jacobs</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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